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Berberine chloride

Name: Berberine chloride
Brand: TargetMol
SKU: T0461
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Natural Yellow 18, Berberine hydrochloride, Benzodioxide) Copy Product Info

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Synonyms: Natural Yellow 18, Berberine hydrochloride, Benzodioxide

Catalog No. T0461 Copy Product Info

Purity: 99.93%

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Berberine chloride (Natural Yellow 18) is an alkaloid derived from Hydrastis canadensis L. of the Berberidaceae family, serving as a commonly used intestinal antibacterial agent. Berberine chloride exhibits biological activities including anti-inflammatory, hypoglycemic, lipid-regulating, antitumor, and cardiovascular protective effects. Berberine chloride can be utilized in research on chronic diseases and tumors.

Cas No. 633-65-8

Pack Size	Price	USA Stock	Global Stock	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.93%

Color:Yellow

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COA HNMR LCMS

Product Introduction

Berberine chloride AI Summary

Berberine chloride demonstrates a broad spectrum of bioactivities, including significant binding affinity to various DNA structures and receptors, leading to varied therapeutic potentials. It exhibits strong inhibitory effects against acetylcholinesterase (IC50 = 374.0 nM) and butyrylcholinesterase (IC50 = 18200.0 nM), highlighting its application in neurodegenerative diseases like Alzheimer’s. The compound shows potent in vitro antimalarial activity against drug-resistant Plasmodium falciparum strains (IC50 = 0.141-0.148 µg/mL) and increases survival time in a murine model of Plasmodium berghei infection, indicating its potential as an antimalarial agent. Additionally, Berberine chloride presents significant antimicrobial activity against various bacterial and fungal pathogens, displaying MIC values ranging from 4.0 to 500.0 µg/mL across different strains, including methicillin-resistant Staphylococcus aureus (MIC = 2.0 µg/mL). It also exhibits antiviral activities, notably inhibiting HIV-1 reverse transcriptase (IC50 = 100.0 µg/mL) and SARS-CoV-2 induced cytotoxicity in cell-based assays. In cancer research, Berberine chloride shows cytotoxicity against multiple cancer cell lines, with IC50 values indicating moderate to potent antiproliferative effects, especially against HT29 and HepG2 cells. The compound has also demonstrated the ability to induce apoptosis and inhibit cell proliferation in various cancer cell lines. Further, Berberine chloride shows promise in cholesterol regulation by increasing LDLR mRNA expression and reducing blood cholesterol levels in hyperlipidemic models. It also activates AMPK, suggesting a role in metabolic regulation. The compound’s profile is complemented by its ability to inhibit enzyme activities related to Alzheimer’s disease, antimalarial efficacy, antimicrobial properties, anticancer potential, and metabolic benefits, making it a versatile candidate for further pharmaceutical development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Berberine chloride (Natural Yellow 18) is an alkaloid derived from Hydrastis canadensis L. of the Berberidaceae family, serving as a commonly used intestinal antibacterial agent. Berberine chloride exhibits biological activities including anti-inflammatory, hypoglycemic, lipid-regulating, antitumor, and cardiovascular protective effects. Berberine chloride can be utilized in research on chronic diseases and tumors.
In vitro	Methods: Copper complexes (0–100 μM), berberine chloride (0–100 μM), and a combination treatment (copper complexes (0–100 μM) + BBC (50 μM)) were added to MDA-MB-231 VIM RFP (triple-negative breast cancer cells) and MCF-10A (normal human mammary epithelial cells). Incubation time: 24, 48, 72 h; cell viability was assessed using the CCK-8 assay. Results: Berberine chloride significantly inhibited cell growth, and combination therapy significantly enhanced cytotoxicity against cancer cells. [1] Methods: LoVo cells were treated with 40 μM berberine chloride for 24 h, and cell cycle distribution was analyzed by flow cytometry. Results: Berberine chloride induced G₂/M phase arrest in LoVo cells. [2]
In vivo	Methods: Using a LoVo cell xenograft model in nude mice, Berberine chloride was administered orally at doses of 10, 30, and 50 mg/kg for 10 consecutive days, and the tumor suppression rate was calculated. Results: The tumor suppression rate for 50 mg/kg Berberine chloride reached 45.3%, with no significant toxicity observed in mouse body weight or spleen.[2]
Synonyms	Natural Yellow 18, Berberine hydrochloride, Benzodioxide

Chemical Properties

Molecular Weight	371.80
Formula	C₂₀H₁₈ClNO₄
Cas No.	633-65-8
Smiles	[Cl-].COc1c(OC)c2c[n+]3c(cc2cc1)c1cc2c(OCO2)cc1CC3
Relative Density.	1.654g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 21.00 mg/mL (56.48 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.00 mg/mL (2.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6896 mL	13.4481 mL	26.8962 mL	134.4809 mL
5 mM	0.5379 mL	2.6896 mL	5.3792 mL	26.8962 mL
10 mM	0.2690 mL	1.3448 mL	2.6896 mL	13.4481 mL
20 mM	0.1345 mL	0.6724 mL	1.3448 mL	6.7240 mL
50 mM	0.0538 mL	0.2690 mL	0.5379 mL	2.6896 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TopoisomeraseReactiveOxygenSpeciesReactive Oxygen SpeciesNatural Yellow-18Natural Yellow18InhibitorinhibitBerberine HydrochlorideBerberine ChlorideBerberineBacterialAutophagyAntibiotic

Related Tags: Berberine chloride chemical structure | Berberine chloride in vivo | Berberine chloride in vitro | Berberine chloride formula | Berberine chloride molecular weight